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What is a Methacholine Challenge Test?
The Methacholine Challenge Test (MCT) is a type of Pulmonary Function Test (PFT) used to diagnose asthma and airway hyperresponsiveness. Methacholine is a substance that, when inhaled, causes mild narrowing of the airways, mimicking the effects of an asthma attack. This test helps physicians determine how reactive your airways are and whether your symptoms may be due to asthma or another respiratory condition.
Doctors may recommend an MCT if you experience symptoms such as shortness of breath, wheezing, chronic cough, or other unexplained respiratory issues despite having normal results on standard lung function tests.
During the procedure, you inhale increasing concentrations of methacholine through a nebulizer. After each dose, spirometry is performed to measure lung function. A drop in lung capacity of 20% or more indicates airway hyperresponsiveness—a key indicator of asthma.
Other PFT Tests
Why Choose a Methacholine Challenge Test?
Highly Sensitive for Asthma Diagnosis
Detects airway hyperreactivity even in mild or intermittent cases
Non-Invasive & Safe
Uses controlled doses of methacholine with medical supervision
Quick & Effective
The test typically lasts 20–40 minutes
Identifies Airway Sensitivity
Helps diagnose patients with normal spirometry but persistent symptoms
Guides Asthma Management
Determines if inhalers or other medications are needed
What Does a Methacholine Challenge Test Detect?
Asthma Diagnosis
Confirms if symptoms are due to asthma or another lung condition
Airway Hyperrespon siveness
Helps identify exercise-induced asthma and occupational asthma
Chronic Cough Evaluation
Determines if an unexplained persistent cough is asthma-related
Reactive Airway Diseases
Diagnoses conditions where airways overreact to triggers
Treatment Effectiveness
Assesses how well current asthma treatments are working
Want to Consult a Doctor Before Your Methacholine Challenge Test?
If you’re unsure whether a Methacholine Challenge Test is necessary, consult a pulmonologist or asthma specialist for expert guidance.
Why Consult a Doctor?
✔️ Get a precise diagnosis for asthma, airway hyperreactivity, or unexplained breathing issues
✔️ Determine if alternative tests like Bronchial Provocation or Spirometry are needed
✔️ Receive expert recommendations on asthma treatment and lung health improvement
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How to Prepare for a Methacholine Challenge Test?
Avoid Caffeine & Smoking for 6 Hours Before the Test – Substances like coffee, tea, and cigarettes can affect results
Stop Using Bronchodilators (if Advised by Your Doctor) – Some asthma medications may interfere with the test
Wear Comfortable Clothing – Loose clothing helps with easier breathing
Follow Doctor’s Instructions – If you have severe breathing issues, your doctor may adjust test preparations
Inform Your Doctor if Pregnant or Have Heart Conditions – Some medical conditions require special precautions
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